Production of Luteoskyrin, a Hepatotoxic Pigment, by Penicillium islandicum Sopp
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چکیده
منابع مشابه
Production of luteoskyrin, a hepatotoxic pigment, by Penicillium islandicum Sopp.
Various factors affecting the yields of luteoskyrin, a hepatotoxic mycotoxin, and related pigments in the liquid medium were studied. Maximal yields of luteoskyrin (0.13% by isolation) and of other pigments were attained in the late phase of the cultivation. The yield of the pigment was increased by supplying malt extract, malonic acid, glutamic acid, or asparagine. A useful material for prepar...
متن کاملProduction of luteoskyrin and isolation of a new metabolite, pibasterol, from Penicillium islandicum Sopp.
Production of luteoskyrin, a hepatotoxin synthesized by Penicillium islandicum Sopp., was studied with various fermentation methods. Best results were obtained in static fermentations on glutinous rice at 30 degrees C. The isolated yield of pure luteoskyrin was approximately 400 mg per kg of rice. Also produced were skyrin, islandicin, iridoskyrin, rubroskyrin, chrysophanol, mannitol, and eryth...
متن کاملProduction of the hepatotoxic chlorine-containing peptide by Penicillium islandicum Sopp.
Twenty-six strains of Penicillium islandicum Sopp were tested for production of a chlorine-containing peptide (Cl-peptide), which is a hepatotoxin. Highest levels of the mycotoxin were produced in a modification of Wickerham medium. The mycotoxin was isolated by adsorption on charcoal and, after washing the charcoal with acetone-water (1:1), was eluted into n-butanol. Further purification was a...
متن کاملBiotin and the biosynthesis of anthraquinoid pigments in Penicillium islandicum Sopp.
By use of liver enzyme preparations, it has been proved that biotin is required for the synthesis of fatty acids (S. J. Wakil, Lipid Res. 2:1, 1961). Biotin-containing enzyme, acetyl-coenzyme A (CoA) carboxylase, catalyzes the first step in the reaction, and the malonyl-CoA produced is the first intermediate of the biosynthesis of the anthraquinoid pigment in fungi (S. Gatenbeck, Acta Chem. Sca...
متن کاملSome recent studies on the metabolites of fungi and lichens.
Various anthraquinonoid colouring matters grouped into (a) monomeric anthraquinones, (b) bianthraquinones and (c) modified bianthraquinones were isolated from Pen icillium islandicum, P. rugulosum, and other fungi. The unusual cagelike structures of hepatotoxic luteoskyrin, (—)rubroskyrin, (+ )rugulosin and their analogues are elucidated. The absolute stereochemical structures of these fungal c...
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ژورنال
عنوان ژورنال: Applied Microbiology
سال: 1969
ISSN: 0003-6919
DOI: 10.1128/aem.18.3.406-409.1969